ABSTRACT
No abstract available.
Subject(s)
Adult , Humans , Male , Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications , Antibodies, Antineutrophil Cytoplasmic/blood , Biomarkers/blood , Biopsy , Drug Therapy, Combination , Fluorescent Antibody Technique , Glomerulonephritis, IGA/complications , Immunosuppressive Agents/therapeutic use , Myeloblastin/immunology , Treatment OutcomeABSTRACT
BACKGROUND/AIMS: Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by attacks of fever and diffuse abdominal pain. The primary concern with this presentation is to distinguish it from acute appendicitis promptly. Thus, we aimed to evaluate the role of neutrophil lymphocyte ratio (NLR) to leverage the differential diagnosis of acute FMF attack with histologically proven appendicitis. METHODS: Twenty-three patients with histologically confirmed acute appendicitis and 88 patients with acute attack of FMF were included in the study. NLR, C-reactive protein and other hematologic parameters were compared between the groups. RESULTS: Neutrophil to lymphocyte ratio was significantly higher in patients with acute appendicitis compared to the FMF attack group (8.24 +/- 6.31 vs. 4.16 +/- 2.44, p = 0.007). The performance of NLR in diagnosing acute appendicitis with receiver operating characteristic analysis with a cut-off value of 4.03 were; 78% sensitivity, 62% specificity, and area under the curve 0.760 (95% confidence interval, 0.655 to 0.8655; p < 0.001). CONCLUSIONS: This study showed that NLR, the simple and readily available inflammatory marker may have a useful role in distinguishing acute FMF attack from acute appendicitis.
Subject(s)
Adult , Female , Humans , Male , Young Adult , Appendicitis/blood , Area Under Curve , Biomarkers/blood , Blood Sedimentation , Diagnosis, Differential , Familial Mediterranean Fever/blood , Inflammation Mediators/blood , Lymphocyte Count , Lymphocytes , Neutrophils , Platelet Count , Predictive Value of Tests , ROC Curve , Reproducibility of Results , Retrospective StudiesABSTRACT
To establish whether the Ischemia-Modified Albumin [IMA], a new parameter of oxidative stress, has diagnostic role in experimental acute pancreatitis. Randomized controlled trial. Experimental Animal Center, Canakkale Onsekiz Mart University, Canakkale, Turkey, from May to September 2013. Sixteen Sprague-Dawley rats were randomly divided into two groups [n=8 each]: Sham and AP groups. AP was induced by ligation of pancreatic duct. Serum IMA, amylase, lipase, AST, ALT and CRP were determined. The severity of pancreatitis was scored by a blinded pathologist under microscope. Serum IMA levels in the AP group increased significantly compared with the control group [p < 0.05]. There was also a strong positive correlation between amylase and IMA levels. The present study showed in a rodent model that serum IMA might serve as an additional marker to monitor inflammation during pancreatitis
ABSTRACT
No abstract available.
Subject(s)
Female , Humans , Middle Aged , Anti-Inflammatory Agents/administration & dosage , Arthritis, Rheumatoid/complications , Cervical Vertebrae/pathology , Infusions, Intravenous , Magnetic Resonance Imaging , Medulla Oblongata/drug effects , Methylprednisolone/administration & dosage , Treatment OutcomeABSTRACT
A two years old boy presented with a transanal protrusion of the ventriculoperitoneal [VP] shunt catheter. A VP shunt was inserted when the boy was six-month-old for congenital hydrocephalus. He was active and neurologically normal, with no signs of meningitis and peritoneal irritation. During laparotomy, the tube was seen entering the sigmoid colon, so the tube was cut at the point where it entered the sigmoid colon. The distal end of the protruding tube was pulled out from the anus. The sigmoid colon was repaired, and a delayed shunt revision was completed. The patient was discharged without abdominal and neurological deterioration